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Figure 8
Schematic illustration showing the proposed solution equilibrium between the two putative conformations of the A and B binding pocket. The entry to the binding pocket is wider for the B than for the A pocket as a result of the water molecule complexed between the Ser117 residues of monomers A and A′. This draws together the dimers, and thereby narrows the A binding pocket.

Volume 1| Part 6| October 2014| Pages 429-438
ISSN: 2052-2525