Figure 1
(a) The sialic acid binding pocket of influenza HA. A ribbon representation of an HA1 trimer is shown in the upper part. The structure of the bound human receptor analogue is shown as red sticks (PDB entry 4bh3
, Xiong et al., 2013). The components of the human (left) and avian (right) receptor analogues are shown in the middle part of the figure and a close-up of the receptor-binding pocket with the superimposition of the two ligands is shown in the lower part. (b) The MV-H protein bound to the receptors: CD46 (PDB entry 3inb
, Santiago et al., 2010; top), Slam (PDB entry 3alz
, Hashiguchi et al., 2011; middle) and nectin-4 (PDB entry 4gjt
, Zhang et al., 2013; bottom). Ribbon drawings, showing the MV-H molecules in blue and the different receptor molecules depicted in red. (c) Structure of the PRCV CoV S-APN complex (PDB entry 4f5c
, Reguera et al., 2012). (d) Structure of the complex MERS-CoV RBD-DPP4 complex (PDB entry 4l72
, Wang et al., 2013). |