Figure 2
The three classes of viral fusion glycoproteins. Ribbon diagrams of the pre-fusion (top) and post-fusion (bottom) conformations of the paramyxovirus (class I; PDB entries 2b9b
, Yin et al., 2006, and 1ztm
, Yin et al., 2005) (a); flavivirus (class II; PDB entries 1svb
, Rey et al., 1995, and 1urz
, Bressanelli et al., 2004) (b); and rhabdovirus (class III; PDB entries 2j6j
, Roche et al., 2007, and 2cmz
, Cho et al., unpublished work) (c) proteins. For each class of fusogen, the equivalent protein domains are highlighted with identical colours and explicitly labelled (DI, yellow; DII, red; DIII, purple; DIV and heptad repeat region A, HRA, light green; HRB, blue; fusion peptide or loops, black). (d) The novel fold of the envelope protein E2 from BVDV (PDB entry 4ild
, Li et al., 2013). (e) The structure of the eukaryotic fusogen EEF1 (PDB entry 4oje
, Pérez-Vargas et al., 2014). |