Data collection approaches. (a) Randomly oriented micro- and nanocrystals can be delivered into the X-ray interaction region using various forms of liquid jets. (b) Large cryo-cooled crystals can be mounted in loops. Serial quasi-rotation data can be collected using a goniometer setup, translating the crystal stepwise by a value Δx,y, an experimentally determined damage zone value, while rotating it by Δφ, a fraction of its experimentally determined mosacity. Other approaches such as chips can also be used.