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Figure 7
General model of signal-peptide binding to SpsB. A surface view showing that the enzyme accommodates the diverse side chains of signal peptides in shallow grooves or on exposed faces (subsites S5, S6 and S1′–S3′), with only the alanine side chains of the canonical Ala-X-Ala buried in the S1 and S3 pockets. The core Ala-X-Ala motif both defines specificity and accounts for the majority of interactions between the peptide and the enzyme, while the `subsites' are such that wide peptide diversity can be accommodated.

ISSN: 2052-2525