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Figure 3
Active site at pH 7.8 of (a) unbound hCA II (Fisher et al., 2011BB18), (b) hCA II in complex with AZM (Fisher et al., 2012BB16) and (c) hCA II in complex with MZM, showing differences in hydrogen-bonding patterns as observed by neutron diffraction at RT. (d) MZM bound in the active site of hCA II as observed by X-ray diffraction at 100 K. MZM binding displaces four water molecules. Change in the orientation of Gln92 (green arrows) also causes a loss of a hydrogen bond to the inhibitor.

IUCrJ
Volume 3| Part 5| September 2016| Pages 319-325
ISSN: 2052-2525
https://doi.org/10.1107/S2052252516010514