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Figure 2
Schematic representation of the relationship between the different EVB diabatic states (1 and 2) in a simple two-state reaction, the corresponding adiabatic reorganization energy (λ) and the resulting activation barriers (ΔG) in water (left) and in an enzyme (right). Both λ and ΔG are significantly smaller in the enzyme, i.e. the enzyme would be a catalyst for this hypothetical reaction (Warshel et al., 2006BB94).

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