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Figure 2
Schematic representation of the relationship between the different EVB diabatic states (∊1 and ∊2) in a simple two-state reaction, the corresponding adiabatic reorganization energy (λ) and the resulting activation barriers (ΔG‡) in water (left) and in an enzyme (right). Both λ and ΔG‡ are significantly smaller in the enzyme, i.e. the enzyme would be a catalyst for this hypothetical reaction (Warshel et al., 2006BB94).

IUCrJ
Volume 4| Part 1| January 2017| Pages 50-64
ISSN: 2052-2525
https://doi.org/10.1107/S2052252516018017