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Figure 14
Left, nuclear 2FoFc density for active-site residues, showing double protonation of His114. Middle and right, amide backbone H/D-exchange pattern for the two monomers of DHFR, ranging from gray (exchanged) to black (not exchanged). Reprinted with permission from Bennett et al. (2006BB2), Proc. Natl Acad. Sci. USA, 103, 18493–18498. Copyright (2006) National Academy of Sciences.

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