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Figure 14
Left, nuclear 2Fo − Fc density for active-site residues, showing double protonation of His114. Middle and right, amide backbone H/D-exchange pattern for the two monomers of DHFR, ranging from gray (exchanged) to black (not exchanged). Reprinted with permission from Bennett et al. (2006BB2), Proc. Natl Acad. Sci. USA, 103, 18493–18498. Copyright (2006) National Academy of Sciences.

IUCrJ
Volume 4| Part 1| January 2017| Pages 72-86
ISSN: 2052-2525
https://doi.org/10.1107/S205225251601664X