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Figure 16
Top, X-ray electron-density map at 0.83 Å resolution showing ambiguous hydrogen-bonding networks in water molecules associated with crambin. Bottom, nuclear density map at 1.1 Å showing the hydrogen-bonding network and clear density for water molecules. Reprinted with permission from Chen et al. (2012BB12), Proc. Natl Acad. Sci. USA, 109, 15301–15306. Copyright (2012) National Academy of Sciences.

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