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Figure 4
Mannose-binding sites of the crystal structures of FimH tyrosine-gate mutants and their complexes with HM and BF. Electron densities are shown at 1.5σ (green) and/or 0.8σ (light blue) (2FoDFc) for the protein and the mannosides and at 1.5σ (2FoDFc) (dark blue) for visible water molecules. The mannose-binding sites of the (a) WT FimH–HM, (b) Y48A FimH–HM, (c) Y137A FimH–HM and (d) WT FimH–BF complexes demonstrate a typical stacking pattern (see text for more details).

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