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Figure 5
Dynamics of α-synuclein in human cell lines. (a) NMR spectra showing the signals from α-Syn in the cytoplasm of two human cell lines (red) and in aqueous buffer (black); decreased signal intensities correspond to regions with different protein dynamics caused by interactions with the cytosol. (b) Intramolecular paramagnetic relaxation enhancement profiles of α-Syn in the cytoplasm (red) and in buffer (grey); the calculated average radius of α-­Syn is smaller in the cytoplasm than in aqueous buffer. Adapted with permission from Macmillan Publishers Ltd.: Nature (Theillet et al., 2016BB63), copyright (2016).

IUCrJ
Volume 4| Part 2| March 2017| Pages 108-118
ISSN: 2052-2525
https://doi.org/10.1107/S2052252516020625