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Figure 4
Schematic to illustrate the concept of drug discovery by exploring biological space encompassing genome information to identify new targets, followed by exploration of chemical space using screening libraries based on knowledge of the target protein structure. The target protein in the illustration is HIV-1 proteinase (PDB entry 3phv) and the drug is HIV-1 proteinase inhibitor (PDB entry 9hvp). The figure is reproduced with permission from Thomas et al. (2017BB111).

IUCrJ
Volume 4| Part 4| July 2017| Pages 308-321
ISSN: 2052-2525
https://doi.org/10.1107/S2052252517009241