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Figure 6
Targeting the interaction between the tumour suppressor BRCA2 and the recombination enzyme RAD51. Protein engineering was used to create a monomeric form of RAD51 by humanizing a thermostable archaeal orthologue, RadA, known as MAYM RadA, and using this protein for fragment screening. View through the Phe pocket of crystal structures of validated fragments. Weighted 2mFoDFc electron-density maps of the partially refined structures are calculated before inclusion of ligands. This figure was created by Dr Marko Hyvönen using material published in Scott et al. (2013BB91).

Volume 4| Part 4| July 2017| Pages 308-321
ISSN: 2052-2525