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Figure 6
Targeting the interaction between the tumour suppressor BRCA2 and the recombination enzyme RAD51. Protein engineering was used to create a monomeric form of RAD51 by humanizing a thermostable archaeal orthologue, RadA, known as MAYM RadA, and using this protein for fragment screening. View through the Phe pocket of crystal structures of validated fragments. Weighted 2mFo − DFc electron-density maps of the partially refined structures are calculated before inclusion of ligands. This figure was created by Dr Marko Hyvönen using material published in Scott et al. (2013BB91).

IUCrJ
Volume 4| Part 4| July 2017| Pages 308-321
ISSN: 2052-2525
https://doi.org/10.1107/S2052252517009241