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Figure 1
The accumulation of deposited coordinates in the Protein Data Bank. The total numbers of deposited coordinates per year are shown as grey bars. The counterparts for all membrane proteins and human membrane proteins are shown as orange and red bars, respectively. The asterisks show the year of the first structure deposition of a membrane protein (orange) and a human membrane protein (red). In the decade after the first structure, the number of deposited coordinates of membrane proteins grew in an exponential manner. This exponential growth implies the contribution of technical breakthroughs such as the usage of recombinant DNA for protein production in the case of soluble proteins in the early 1980s.

IUCrJ
Volume 4| Part 5| September 2017| Pages 529-539
ISSN: 2052-2525
https://doi.org/10.1107/S2052252517008193