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Figure 4
Copper-site comparison of dioxygen-binding enzymes. (a) Superposition of the SF-ROX AxNiR resting-state T2Cu site and dioxygen-bound PHM. AxNiR is shown in green and PHM is shown in yellow, with the Cu atoms shown in cyan and brown, respectively. AxNiR coordinate bonds are shown in red, with PHM coordinate bonds shown in blue. PHM is from PDB entry 1sdw (Prigge et al., 2004BB36). The PHM copper has His2–Met coordination. Both structures have an end-on-bound dioxygen (shown in red). (b) Superposition of the SF-ROX AxNiR resting-state T2Cu site and the reduced bovine SOD Cu site. AxNiR is shown in green and Cu,Zn-SOD is shown in purple, with their Cu atoms shown in cyan and dark grey, respectively. AxNiR coordinate bonds are shown in red, with SOD coordinate bonds shown in green. Bovine Cu,Zn-SOD is from PDB entry 1q0e (Hough & Hasnain, 2003BB25). The copper sites display similar His3 ligation. The NiR HisCAT occupies a similar position to the SOD bridging imidazole.

IUCrJ
Volume 5| Part 1| January 2018| Pages 22-31
ISSN: 2052-2525
https://doi.org/10.1107/S2052252517016128