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Figure 1
Multi-model imaging of the interaction of nanoparticles with a mammalian cell. (a) Three-dimensional image of a macrophage incubated and treated with Gd@C82(OH)22 nanoparticles, showing the nucleus (brown), various lysosomes (yellow) and the nanoparticle (dark red). The image was obtained by combining dual-energy X-ray microscopy with an advanced three-dimensional reconstruction algorithm, termed equal slope tomography (EST). (b) Distribution of the nanoparticles in a two-dimensional projection of the macrophage. (c) Three-dimensional intracellular distribution of the nanomaterials. (d) X-ray fluorescence microscopy image of the macrophage. The scale bar corresponds to 2.0 µm.

IUCrJ
Volume 5| Part 2| March 2018| Pages 122-123
ISSN: 2052-2525
https://doi.org/10.1107/S2052252518003548