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Figure 4
The five motifs (blue) that are conserved across all available sequences of the Arenaviridae endonuclease domain plotted on the LCMV structure (grey). Conserved motifs are shown in WebLogo representation. The size of the letter is representative of the frequency with which it observed in the alignment (with a probability of 1 being identity). The numbering of the residues refers to the sequence of LCMV. Motifs 1–4 represent the four positions that can be used to anchor a ligand over all Arenaviridae. Residues marked with a star correspond to key residues involved in the active site or in substrate binding, and their side chains are highlighted on the structure (orange).

Volume 5| Part 2| March 2018| Pages 223-235
ISSN: 2052-2525