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Figure 5
The intracellular distribution of nanomaterials. (a) Volume rendering of the reconstructed macrophage showing [Gd@C82(OH)22]n (dark red), nucleus (brown) and different types of lysosomes (yellow). (b) Organelle segmentation based on differences in the linear absorption and specific morphology. (c) Three-dimensional distribution of [Gd@C82(OH)22]n, showing that the NPs aggregate and exhibit a characteristic distribution in the cell. (d) Enlarged view of the nucleus in three dimensions showing that the NPs were distributed in four separated lysosomes on the surface of the nucleus. (e) Three different types of lysosomes were distinguished based on the density and distribution of [Gd@C82(OH)22]n, which may reflect the intracellular transportation of the nanomaterials.

IUCrJ
Volume 5| Part 2| March 2018| Pages 141-149
ISSN: 2052-2525
https://doi.org/10.1107/S2052252517017912