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Figure 3
The conformational change leading to the opening of the substrate-access channel. (a) Conformation of RpNiR in the resting state showing only the presence of the proton-delivery/product-release channel (magenta). (b) Activation of Tyr323 leads to opening of the substrate-access channel (orange) with the proton-delivery channel remaining unaltered. The new channel that is opened as a result of tyrosine activation is the same channel as is used for substrate access in all two-domain CuNiRs.

IUCrJ
Volume 5| Part 4| July 2018| Pages 510-518
ISSN: 2052-2525
https://doi.org/10.1107/S2052252518008242