Figure 1
(a) Naftopidil (1) and coformers benzoic acid (2), 2-hydroxybenzoic acid, (3) 2,3-dihydroxybenzoic acid (4), 2,4-dihydroxybenzoic acid (5) and 2,6-dihydroxybenzoic acid (6) used for cocrystallization; and (b) the ionic synthon of the (9) graph set that is observed in all single-crystal structures (salts). In the synthon, complete proton transfer produces an N+—H⋯O− and O—H⋯O hydrogen-bonded cyclic motif. |