Figure 3
Synthesis of multicomponent organic-salt alloys: the first five binary salts [(12), (13), (14), (15) and (16)] were synthesized and their structures analyzed. All binary salts are isostructural. Similarly ternary, quaternary and pentanary crystal alloys were crystallized. Cocrystallization of naftopidil (1) (1.0 mmol) with benzoic acid (2), salicylic acid (3), 2,3-dihydroxybenzoic acid (4), 2,4-dihydroxybenzoic acid (5) and 2,6-dihydroxybenzoic acid (6) (0.2 mmol of each coformer) resulted in a 6-component organic-salt alloy (hexanary alloy). |