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Figure 1
Structures. (a) GluA2 in the resting (apo) state (PDB entry 4u2p; Dürr et al., 2014BB4), the activated state (PDB entry 5weo; Twomey et al., 2017BB59b), the desensitized state (PDB entry 5vhz; Twomey et al., 2017aBB53) and with a negative allosteric modulator bound (PDB entry 5l1h; Yelshanskaya et al., 2016BB57). The N-terminal domain (NTD), ligand-binding domain (LBD) and transmembrane domain (TMD) are indicated in the figure. Parts of the TMD have not been modelled in the structures. (b) The EM class 3 structure (EMDataBank EMD-2688; Meyerson et al., 2014BB30). (c) The agonist AMPA. (d) The negative allosteric modulator GYKI-53655.

IUCrJ
Volume 5| Part 6| November 2018| Pages 780-793
ISSN: 2052-2525
https://doi.org/10.1107/S2052252518012186