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Figure 3
SANS data for GluA2 in the presence of AMPA at pH 7.5. (a) Experimental SANS data (grey points) and the resulting structure fits and residual plots for the crystal structure of GluA2 in the resting state (PDB entry 4u2p; cyan; Dürr et al., 2014BB4), GluA2 in the activated state (PDB entry 5weo; black; Twomey et al., 2017bBB59), GluA2 in the desensitized state (PDB entry 5vhz; red; Twomey et al., 2017aBB53) and GluA2 in the class 3 EM structure (EMD-2688; magenta; Meyerson et al., 2014BB30). A cartoon representation of the three structures overlaid is shown in the respective colours. (b) p(r) functions for the SANS data (light grey points) and for a truncated data set (q ≥ 0.011 Å−1; dark grey points) with the p(r) for four structures. (c, d) Resulting fits and p(r) functions for linear combinations of the atomic structures and fractal oligomers. (e, f) Resulting fits and p(r) functions for combinations of the atomic structures and the class 3 EM structure.

IUCrJ
Volume 5| Part 6| November 2018| Pages 780-793
ISSN: 2052-2525
https://doi.org/10.1107/S2052252518012186