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Figure 6
Proposed model for canonical hexamer assembly. Individual monomers (a) start to nucleate a protomer via β-sheets I/I′ (b). Next, the SM1/1′ and SM2/SM2′ flexible regions from β-sheets II/II′ are stabilized in the nascent protomer, resulting in favoured additional intersubunit interactions within the protomer (c). Final stabilization is attained with the proper folding of SM3′ and of the ClA and ClB motifs that allow the binding of chloride ions (green spheres) (d). The two protomers in the hexamer are now ready to be joined by sulfilimine bonds (red lines).

IUCrJ
Volume 5| Part 6| November 2018| Pages 765-779
ISSN: 2052-2525
https://doi.org/10.1107/S2052252518012459