Computational design of symmetrical eight-bladed β-propeller proteins

Noguchi, H.; Addy, C.; Simoncini, D.; Wouters, S.; Mylemans, B.; Van Meervelt, L.; Schiex, T.; Zhang, K.Y.J.; Tame, J.R.H.; Voet, A.R.D.

doi:10.1107/S205225251801480X

Figure 4
Comparison of the parent, Tako and Ika propeller structures. (a) The overall β-propeller domain is depicted as a cartoon coloured from blue to red from the N-terminus to the C-terminus. (b) Superposition of the individual blades of the different proteins indicates that the parent protein does not exhibit a conserved backbone geometry, while the eight blades of Tako8 can be perfectly aligned. In the case of Ika8 only the alternating a and b repeats can be perfectly aligned. The differences in symmetry are also clear from the electrostatic potential as calculated by APBS (Touw et al., 2015