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Figure 2
Binding-site interactions in PAF–sclxn. (a) sclx4, (b) sclx6 and (c) sclx8 binding to PAF at Lys30. Note the altered conformations of Lys30 and Phe31 in each structure, while Pro29 provides a rigid hydrophobic surface for face-to-face interaction with sclx6 and sclx8. In PAF–sclx8, two protein chains interact with the calixarene. PEG fragments equivalent to tetraethylene glycol and heptaethylene glycol were bound to sclx6 and sclx8, respectively.

Volume 6| Part 2| March 2019| Pages 238-247
ISSN: 2052-2525