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Figure 1
Structure-based sequence alignment of the T2Cu–T1CuN amino-acid region of TsNirK. (a) Diagrammatic representation of polypeptide sequence and domain distribution in NirKs. (b) Alignment of the sequences in the T1Cu–T2Cu core region of 37 NirKs (putative or well characterized) performed with Geneious 7.0. A detailed protein-source nomenclature is shown in Fig. S1. Sequence alignment corresponding to the sensing-loop region (on the left in red) and alignment of the amino-acid sequence that connects the Cys with the axial ligand (AxL) (on the right in blue). In the centre, a cartoon shows structural detail of regions in TsNirK. (c) A cartoon arrangement for RpNiR, HdNir, TsNirK and PhNir. Metal cofactors are shown as dots and coloured according to their domains. The additional fused domains (cupredoxin/cytochrome) are shown as circles.

IUCrJ
Volume 6| Part 2| March 2019| Pages 248-258
ISSN: 2052-2525
https://doi.org/10.1107/S2052252519000241