Architecture of TpH. (a) Cryo-EM structure of TpH decamer in side, top and bottom view. The ten protomers are highlighted in color. (b) Five protomer-dimers viewed from inside the cylinder. Colors correspond to those of (a). FUs of the inner collar (g and d*) are indicated. FU-gs forming FU-g dimers are indicated. (c) Schematic of the decameric assembly shown with the cylinder unrolled and shown from inside. FU-g dimers are highlighted by the surrounding white background. Colors of each protomer correspond to those of (a) and (b). The arrow indicates the region of the symmetry break.