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Figure 1
(a, b) Mean size and distribution of the largest solvent cavity within the unit cell versus solvent content and unit-cell volume obtained from 17 148 nonredundant protein structures in the PDB, excluding small peptides and viral proteins. Symbols indicate mean values and the shading indicates the region within one standard deviation of the maximum of the distribution. The solid line fitted in (b) has the form (cavity size) ∝ (cell volume)1/3, so cavity size scales with linear unit-cell dimension. (c, d) Histograms of PDB entry distributions versus solvent content and largest solvent cavity for soluble proteins (blue) and membrane proteins (orange). The corresponding values for cubic apoferritin, tetragonal thaumatin and tetragonal lysozyme crystals are marked in each frame.

IUCrJ
Volume 6| Part 3| May 2019| Pages 346-356
ISSN: 2052-2525
https://doi.org/10.1107/S2052252519001878