Ligand pathways in neuroglobin revealed by low-temperature photodissociation and docking experiments

Ardiccioni, C.; Arcovito, A.; Della Longa, S.; van der Linden, P.; Bourgeois, D.; Weik, M.; Montemiglio, L.C.; Savino, C.; Avella, G.; Exertier, C.; Carpentier, P.; Prangé, T.; Brunori, M.; Colloc'h, N.; Vallone, B.

doi:10.1107/S2052252519008157

Figure 1
Large hydrophobic cavity and O₂-docking sites in Ngb. The determination of neuroglobin structures in 2004 unravelled the existence of a large hydrophobic internal cavity in which the heme is accommodated, along with the main `tunnel' and an alternate tunnel connecting this cavity to the bulk. The internal cavity and tunnels are shown in green (a) for hexacoordinate ferric Ngb (PDB entry 1q1f; Vallone, Nienhaus, Brunori et al., 2004