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Figure 6
Schematic drawings showing the relative positions of the BIR2 and BIR3 domains and the distance between cysteines in the XIAP dimer and in complexes with different partners. (a) XIAP homodimer based on a representative model from the HADDOCK calculations performed in the present study. (b) Two BIR2 domains in complex with a caspase-3 dimer (PDB entry 1i3o; Riedl et al., 2001BB45). (c) Two BIR3 domains in complex with a Smac/DIABLO dimer (PDB entry 1g73; Wu et al., 2000BB61). (d) Two BIR2-BIR3 constructs in complex with a Smac/DIABLO tetramer based on a SAXS-derived model (Mastrangelo et al., 2015BB34). XIAP domains are labelled with the initial letter of each name; inter-cysteine distances are shown in (a), (b) and (c).

IUCrJ
Volume 6| Part 5| September 2019| Pages 948-957
ISSN: 2052-2525
https://doi.org/10.1107/S205225251901073X