view article

Figure 2
Hydrophobicity and surface charges. Hydrophobicity maps (Kyte & Doolittle, 1982BB20; arbitrary units, from −4.5 to 4.5) of surface-exposed residues for individual subunits are shown oriented so that the outer surface (a, top) or the surface that accepts the N-terminal extension from the adjacent subunit (b, bottom) is visible. The charge distribution (in kcal mol−1 at 25°C) on the outer surface (c) and the inner surface (d) of the pilus shows a negatively charged inner surface that could provide a target for positively charged disruptive therapeutic molecules/peptides such as histatins (Brown et al., 2018BB8).

Volume 6| Part 5| September 2019| Pages 815-821
ISSN: 2052-2525