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Figure 1
Structure of promirolysin reveals how the pro-segment inhibits enzyme activity prior to proteolytic activation. The N-terminal residues of the pro-segment (salmon) occupy the active site cleft of the catalytic domain (gray), with a key cysteine residue coordinating the catalytic zinc ion (purple). This figure was generated using Pymol from the coordinates of PDB structure 6r7v, reported in this issue by Guevara, Rodriguez-Banqueri et al.

ISSN: 2052-2525