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Figure 1
Chip geometry and design. (a) Final 3D-printed chip with tubing inlets and Kapton windows. The device is very small (8.88 × 23.10 × 2.32 mm) and has three inlet channels (two outer channels for the buffer and one central channel for the sample; top of image) and one waste outlet (bottom of image). The central device area is tapered to yield a thin, open central channel (430 × 280 µm vertical × horizontal; Supplementary Fig. S1) which is later sealed with Kapton HN foil. This is the X-ray-interaction region. (b) Schematic drawing. Two orthogonal central planes of the device showing the sample speed as calculated from computational fluid dynamics (CFD) simulations. The sample flows from the central inlet (S) and is focused by the perpendicular buffer inlets (B). (c) Cut-through view of the device at the sample inlet, showing the centering of the sample channel (yellow box) in the chip body and the minimal printable bottom layer height (green box). The sample-inlet channel is shallower than the buffer channels (200 µm versus 430 µm in height; both are 280 µm in width), causing the buffer to fully surround the sample (sides, top and bottom), focusing the sample in the center of the stream. (d) Perspective view of the channels and flow-focusing region to scale showing the normalized sample concentration of the focused sample stream (CFD data) and the direction of the X-ray beam. The inset depicts the channel cross-section from the perspective of the flow direction, with the beam width and crystal sizes represented to scale.

Volume 7| Part 2| March 2020| Pages 207-219
ISSN: 2052-2525