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Figure 1
Overall structure of the MICU1–MICU2 heterodimer and the B–B dimer of MICU2 in an ASU. (a) Schematic diagram of MICU1 and MICU2. MICU1 and MICU2 consist of mitochondrial targeting sequences (S), N lobes, bridge helices (B), C lobes, and C-terminal helices (H). MICU1 and MICU2 contain two canonical EF hands (EF-hand 1 and EF-hand 4) and two non-canonical EF hands (EF-hand 2 and EF-hand 3). (b) A cartoon representation of the overall structure of the MICU1–MICU2 heterodimer. Interface 1, comprising the MICU1 N lobe and the MICU2 C lobe, is highlighted in the cyan square. Interface 2, comprising the MICU1 C lobe and the MICU2 N lobe, is highlighted in the yellow square. (c) A cartoon representation of the B–B MICU2 dimer in the ASU. (d) A ribbon and cylindrical diagram of the superimposed AB and CD dimers based on MICU1, and a table of RMSD values between each heterodimer. MICU1 is colored green or violet and MICU2 colored yellow or cyan. The tilt angle is marked with a black arrow.

IUCrJ
Volume 7| Part 2| March 2020| Pages 355-365
ISSN: 2052-2525
https://doi.org/10.1107/S2052252520001840