Figure 2
Structural comparison between the MICU1–MICU2 heterodimer and other homodimers of MICU1 and MICU2. (a)–(c) Space-filling model of the MICU1–MICU2 heterodimer (Mol CD), an apo MICU1 homodimer (PDB ID 4nsc; Wang et al., 2014) and an apo MICU2 homodimer (F–F) (PDB ID 6agh; Xing et al., 2019). The red regions indicate the interface areas. (d) Representations of the RMSF based on the ensemble refinements of MICU1 (Mol A and C) or MICU2 (Mol B and D) in the MICU1–MICU2 heterodimer. (e) A ribbon and cylindrical diagram of superimposed apo MICU2 (purple) (PDB ID 6agh) and B–B dimer (yellow and cyan) among MICU1–MICU2 heterodimers in the ASU. The tilted regions are marked with black arrows. |