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Figure 2
Theoretical modelling of the changes in structural parameters as a function of the mixtures of two conformers. (a) Theoretical SAXS profiles of three ligand-triggered population transitions, following open versus closed leucine-binding protein (LBP), T versus R states of aspartate carbamoyltransferase (ATCase) and dimeric versus hexameric forms of human ribonucleotide reductase (hRNR). Profiles were computed by CRYSOL based on crystal structure coordinates, see the main text for details. (b) Corresponding structural parameters computed from a mixture of two conformations for VR, Rg and Vc. VR values were calculated over 0–2 nm−1 for LBP and ATCase, and over 0–1 nm−1 for hRNR.

Volume 7| Part 4| July 2020| Pages 644-655
ISSN: 2052-2525