Deep learning enables the atomic structure determination of the Fanconi Anemia core complex from cryoEM

Farrell, D.P.; Anishchenko, I.; Shakeel, S.; Lauko, A.; Passmore, L.A.; Baker, D.; DiMaio, F.

doi:10.1107/S2052252520009306

Figure 4
Model validation by mutational and cross-linking data. (a) 30 nonbenign human mutations mapped to our model of FAcc. All interface mutations are marked with magenta spheres; non-interface mutations are marked with tan spheres. (b) Close-up renderings of cross-links throughout the FAcc model. Black lines indicate cross-links that are satisfied (<30 Å) by the final refined structure. Representatives from each cross-link cluster are shown for the middle lobe (left) and the bottom lobe (right).

IUCrJ

Volume 7| Part 5| September 2020| Pages 881-892

ISSN: 2052-2525

https://doi.org/10.1107/S2052252520009306

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