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Figure 1
Schematic diagram of the phospho­relay in HptB-mediated hybrid TCS. The P. aeruginosa gene index numbers of the orphan sensors and the response regulator are listed in parentheses. Blue arrows indicate the phospho­ryl transfer in the pathway. The phospho­ryl group is presented with an encircled P. After activation with environmental stimuli, sensor histidine kinases (PA1611, PA1976, PA2824 and PA4856) auto­phospho­rylate and transfer the phospho­ryl group specifically to HptB, which in turn relays the signal to response regulator PA3346. The phospho­rylation regulates the Ser/Thr phosphatase activity of PA3346, resulting in increased phosphatase activity and de­phospho­rylation of the anti-sigma antagonist PA3347 (indicated with a red arrow). The phospho­rylation/de­phospho­rylation status might modulate the binding activity of PA3347 to other factor(s) and lead to the regulation of genes associated with swarming activity and biofilm formation.

IUCrJ
Volume 7| Part 5| September 2020| Pages 934-948
ISSN: 2052-2525