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Figure 6
A comparison of the 11 independent views of the pose of GC376 bound to 3CLpro. Superposed inhibitor molecules in seven structures are shown, PDB entries 6wtj, 6wtk, 6wtt (chains A, B and C), 7c6u, 7c8u, 7cbt (chains A and B) and 7d1m (chains A and B), with chain A of 7d1m serving as a reference. The GC376 inhibitors are shown in ball-and-stick representation with C atoms in green, O atoms in red and N atoms in blue. The surface represents all 11 overlapped ligands in their respective atomic colors. The protease backbone is shown in gray and the side chain of the catalytic Cys145, at the inhibitor–enzyme covalent link, is labeled.

Volume 8| Part 2| March 2021| Pages 238-256
ISSN: 2052-2525