Figure 5
Disorder and hydrogen-bond patterns surrounding the His15 side chain. A representation is shown of the overall environment around His15 in D-HEWLEC (a), D-HEWLPP (b) and H-HEWL (c). The 2Fo − Fc electron-density maps represented are contoured at 1σ. Highlighted hydrogen-bond interactions correlated with His15 side-chain disorder are shown for conformation A of D-HEWLEC (d), D-HEWLPP (e) and H-HEWL (f) and for conformation B of D-HEWLEC (g), D-HEWLPP (h) and H-HEWL (i). |