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Figure 1
(a) NaK ion channel composed of four subunits, each of which is formed from a separate polypeptide. Each of the four polypeptides or subunits are shown in a different color with the ions within the SF shown as orange spheres. (b) Overlay of the alpha carbon traces of the two polypeptide chains in our NaKΔ19 structure. The A polypeptide chain is shown in magenta, and the B polypeptide chain is shown in cyan. The SF forms the ion channel pore, next to that is the pore helix, which is flanked by the long inner helix, the outer helix is located at the periphery of the ion channel. (c) SF of the NaK ion channel shown in stick format with ions in the SF shown as orange spheres. For clarity only two of the four subunits that make up a complete ion channel are shown.

Volume 8| Part 3| May 2021| Pages 421-430
ISSN: 2052-2525