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Figure 7
Structural comparison of the substrate-free structure and papaverine complex with CYP105D18. (a) Superposition of substrate-free CYP105D18 with papaverine-bound CYP105D18 colored blue and orange, respectively. The BC loop and turn of αF–αG of CYP105D18 are shown as ribbon diagrams. (b) Close-up view of the αB′ and hinge region of the active site. (c) Close-up view of the heme and papaverine-binding site. The papaverine and interacting residues are shown as stick models. Yellow stick models indicate papaverine. Bound heme molecules are also indicated by stick models.

Volume 8| Part 4| July 2021| Pages 684-694
ISSN: 2052-2525