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Figure 4
Expected binding mode of MtHigA2. HigA shows diverse dimerization modes. The major contributor to dimerization is highlighted and HTH motifs are coloured in a darker shade. The distance between two HTH motifs is shown in Å. The DNA-bound structures are available for M. tuberculosis and P. aeruginosa and toxin–antitoxin complex structures are available for V. cholerae and E. coli HigA. From the comparison, we could model the DNA-binding mode and toxin-binding mode of MtHigA2 (coloured in cyan). PDB codes are shown below the structures.

IUCrJ
Volume 8| Part 5| September 2021| Pages 823-832
ISSN: 2052-2525
https://doi.org/10.1107/S2052252521007715