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Figure 5
MtHigBA2 operon and action of MtHigA2. Based on our results, a schematic of the MtHigBA system is suggested. MtHigA2 is translated downstream of MtHigB2. Upon translation, the N-terminus of MtHigA2 is autocleaved and structural rearrangement occurs to bind DNA, thereby blocking additional expression of the HigBA operon. When the MtHigB toxin is expressed, MtHigA2 with an intact N-terminus binds to the toxin and neutralizes it.

Volume 8| Part 5| September 2021| Pages 823-832
ISSN: 2052-2525