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Figure 5
(a) Structural superposition of MCE domains from Mtb (MtMce4A39–140; pink), E. coli (EcMlaD; PDB entry 5uw2; yellow) and A. baumannii (AbMlaD; PDB entry 6ic4; blue). (b) Cartoon representation of the hypothetical homohexamer of MtMce4A39–140 (pink) generated based on the EcMlaD homohexamer (yellow). The residues from two monomers (chains A and B) involved in the steric clashes are shown as spheres and sticks in blue and red. These clashes are between β2–β3 loop residues Lys61, Tyr62 and Arg63 of chain A and β3–β4 loop residues Ser76, Gyl77 and Gln79 of chain B, between β5 strand residue Ala103 of chain A and β5–β6 loop residue Ile107 of chain B, between β6 strand residue Glu114 of chain A and β5–β6 loop residue Ala50 of chain B, and between β7 strand residue Leu140 of chain A and β5–β6 loop residues Thr106 and Ile107 of chain B.

IUCrJ
Volume 8| Part 5| September 2021| Pages 757-774
ISSN: 2052-2525
https://doi.org/10.1107/S2052252521006199