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Figure 3
Comparison of substrate-bound Mpro/C145A from SARS-CoV-2 (PDB entry 7n89) with Mpro/H41A from SARS-CoV (PDB entry 2q6g). (a) Protomer A in Mpro/C145A–substrate from SARS-CoV-2 (orange protein, green substrate) superimposed on the SARS-CoV Mpro/H41A–substrate complex (cyan protein, slate substrate). Superposition was by a least-squares fit of Cα atoms of protomer B in PDB entry 2q6g to protomer A in PDB entry 7n89. (b) Protomer B in Mpro/C145A–substrate from SARS-CoV-2 (orange protein, green substrate) superimposed on the SARS-CoV Mpro/H41A–substrate complex. Superposition was by a least-squares fit of Cα atoms of protomer A in PDB entry 2q6g to protomer B in PDB entry 7n89.

IUCrJ
Volume 8| Part 6| November 2021| Pages 973-979
ISSN: 2052-2525
https://doi.org/10.1107/S2052252521010113