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Figure 4
(a) Conformational changes of Trp107 associated with DSM binding in the β-barrel of the FAW–DSM#1 complex (green); the conformation of Trp107 in the unliganded protein is shown in orange. (b) Differences in the conformation of Trp107 and the position of DSM between FAW–DSM#1 (light green) and FAW–DSM#3 (light violet). (c) Conformational changes of Phe107 in FAF related to the ligand type accommodated in the β-barrel: Phe107 in unliganded FAF (light green), the conformation of Phe107 and the position of the ligand in the FAF–DSM complex (salmon) and the conformation of Phe107 and chlorpromazine in the FAF–CPZ complex (PDB entry 5nuk, violet).

IUCrJ
Volume 9| Part 3| May 2022| Pages 386-398
ISSN: 2052-2525
https://doi.org/10.1107/S2052252522004183