Figure 5
(a) and (b) Correlation of IDR and EqSol of multicomponent forms. (c) and (d) Correlation of IDR of the multicomponent forms and EqSol of the respective guest molecules. Note, nicotinamide is not included here since its EqSol is several orders of magnitude higher compared with the EqSol values of other guest molecules. Cocrystals are marked with black circles, solvates with blue diamonds and pure apremilast with red squares. (a) and (c) Linear plots; (b) and (d) log–log plots. A logarithmic fit of the data in (a) gives an R2 of 0.56 with outliers and an R2 of 0.94 without outliers marked with black circles. A linear fit of the data in (b) gives an R2 of 0.76. |