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Figure 2
Comparative structural analysis of HipBA systems. (a) Structure-guided sequence alignment of H. influenzae HipAN with the N-terminal parts of other HipAs. The secondary structural organization of H. influenzae HipAN is displayed on the alignment. Conserved residues are highlighted in red and yellow. (b) Structural com­parison of H. influenzae HipAN and HipBA systems from other organisms. Residues showing high conservation are marked in the overlay. HipBA binding inter­faces of E. coli and S. oneidensis are identified in circles and enlarged in squares. (c) Structural com­parison of HipB antitoxins from E. coli O127:H6 (PDB code: 7ab3) and S. oneidensis (PDB code: 4pu3) using E. coli HipB antitoxin bound to the DNA (PDB code: 5k98) structure as model.

Volume 9| Part 5| September 2022| Pages 625-631
ISSN: 2052-2525